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In 2002, Arizona’s Flinn Foundation began implementing a strategy that focused on boosting its state’s bioscience economy and relied heavily on building collaborative partnerships. Since that time, Arizona has had dramatic increases in jobs, research funding, businesses, and wages within the bioscience sector. This case study illustrates the benefits of taking a strategic approach to maximize a foundation’s impact. It describes how Flinn’s leaders narrowed the Foundation’s focus and assessed its performance.