Zika Virus Infection in Mice Causes Panuveitis with Shedding of Virus in Tears

Publication date: 
September, 2016
Source(s): 
Cell Reports

Zika Virus Infection in Mice Causes Panuveitis with Shedding of Virus in Tears

ZIKV is a mosquito-transmitted flavivirus that is closely related to Dengue (DENV), West Nile (WNV), and yellow fever (YFV) viruses.

Beyond the clinical syndromes of microcephaly, intrauterine growth restriction, and fetal demise, several clinical studies have observed eye malformations and pathology in neonates born to mothers infected with ZIKV during pregnancy.

Manifestations of eye disease in newborns with ZIKV include chorioretinal atrophy, optic neuritis, bilateral iris colobomas, intraretinal hemorrhages, lens subluxation, and blindness...

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