Rats Replay Memories Forward and Backwards to Make Decisions, Understanding the Memory Process Will Lead to Treatments for Diseases Where Memory is Impaired, Research Funded by the Alfred P. Sloan Foundation
The researchers found that specific patterns of brain cell firings in rats correspond to individual memories. As a result, the researchers could tell what the rodents were remembering during an experiment. They also found a way to predict what the animals would do next.
During sleep, the brain replays each memory from the day in a unique pattern of brain cell firings. The activation of a pattern essentially creates a recording of the memory so it can be stored for the long term. This process, called memory consolidation, occurs while we’re awake, too.
In the long term, the researchers hope that a greater understanding of how the brain processes memories will lead to treatments for diseases where memory is impaired, such as Alzheimer’s disease or other kinds of dementia.
MEMORY CONSOLIDATION FOR DECISION TIME
Shantanu Jadhav, assistant professor of psychology at Brandeis University, and his collaborators designed a W-shaped maze. Each prong of the W held small wells with a tasty rat treat. A rat entering the maze on the right would find the nearest treat in the center. After that, the nearest treat would be on the left.
It worked in the opposite direction as well; after noshing on the left, the rodent went to the center, and then back to the right. Over the course of 6 to 8 hours, the rats formed separate memories of each of the four parts of a roundtrip journey—right to center, center to left, left to center, and center to right. Each part corresponded to a unique and identifiable pattern of brain cell firings.
When the rats arrived in the center of the maze, they paused for several seconds. During this time, they pondered their next move. They could go back to where they came from (no treat) or they could continue to the opposite side of the W (treat!).
The scientists monitored the rats’ decision-making process in real time. First, the rats replayed the sequence of brain cell firings from a memory of one of the four legs of their journey. But what surprised the scientists was that the rats’ brains played the sequence in reverse order, rewinding the recording of the memory. This process is called reverse replay and enables the rats to recall the past in order to decide what to do next...