Doris Duke Foundation Announces "Racial Equity in Clinical Equations"

Tuesday, June 27, 2023

Doris Duke Foundation Announces "Racial Equity in Clinical Equations"


Initiative Launches with Landmark Convening and Over $10 Million in New Grants

Largest Commitment Ever to Examine the Misuse of Race in Medical Research Informing Patient Care

New York – June 27, 2023 – The potentially improper use of race in the design of clinical algorithms – mathematical models used to guide disease diagnosis and treatment – can lead to profound racial disparities in health care outcomes. Today, the Doris Duke Foundation (DDF) steps forward to address this problem with Racial Equity in Clinical Equations, a new initiative launching with a landmark convening and the largest ever investment in gathering the evidence necessary to inform change.

Attention to the potentially dangerous results of race misuse in clinical equations is growing, as physicians, policymakers, and patient advocates have begun to scrutinize formulas used to inform evaluations such as the diagnosis of kidney disease and transplant allocationpediatric care including urinary tract infections in toddlers, and the ability to have a vaginal birth after C-section. What is critically necessary is a concerted and collaborative movement among funders, researchers, clinicians and patients to develop a more rigorous approach to how race is applied and understood in the design of clinical algorithms and the assessments they inform.

The Doris Duke Foundation aims to fuel such a movement with this initiative. The goals of Racial Equity in Clinical Equations are to increase awareness of the problem within the medical research community, to build support for the examination and revision of clinical algorithms that improperly use race, and to generate evidence that can inform new guidelines to help shape clinical equations that improve health care outcomes.

The work is urgent. Race may or may not be a relevant factor in individual formulas that inform medical decision-making, but a failure to consider the downstream impact of choosing – or excluding – race as an element in clinical equations can have disastrous results, potentially leading to the over, under, or misdiagnosis of disease, delayed treatment, and negative outcomes in patients of color.

Racial Equity in Clinical Equations addresses this concern. The initiative begins with a summit in partnership with The Gordon and Betty Moore Foundation, the Council of Medical Specialty Societies and the National Academy of Medicine, and with over $10 million in new Doris Duke Foundation grants – the largest investment to date to provide data that can effect progress on this issue. The summit will draw together powerful stakeholders in the clinical, research, funding, and policy realms to learn about ongoing efforts, and identify opportunities to address the misuse of race in formulas guiding medical decision-making head on.

Racial Equity in Clinical Equations grants will document the impact on patients of existing algorithms with potential race misuse, provide vital data to inform new guidelines, and ultimately enable the medical research community to identify a framework to reconsider and potentially revise current and future mathematical models that underlie patient care.

“Great science advances equity through excellence,” comments DDF President and CEO Sam Gill. “These grants will help ensure we bring the highest scientific rigor to the consideration of race in clinical algorithms so that we can begin to close intolerable racial disparities in health outcomes.”

The Foundation has awarded the new grants to five organizations that are well positioned to bring together large medical and research communities in high impact disease areas to rigorously study the consequences of, and potential for, race misuse in existing clinical algorithms, disseminate findings, set norms, and issue recommendations to influence research and clinical practice, and policy. The national and local organizations listed below stand out for their top leadership commitment to health equity (please see the end of this release for more information on their projects, and links to further detail).

  • The American Academy of Pediatrics
  • The American Heart Association
  • The American Society of Hematology
  • The Coalition to End Racism in Clinical Algorithms
  • The National Academy of Sciences

“Clinicians need tools developed through rigorous research that validate the instruments’ performance and ensure patient safety”, comments DDF Program Director for Medical Research Dr. Sindy Escobar Alvarez. “Taking bold steps to revisit even the most standard healthcare tools with openness and creativity is integral to the research community’s responsibility to evolve and improve conventional wisdom for the benefit of human health – for all...

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